![]() ![]() As expected, these analyses unequivocally confirmed APOE's risk effect (rs2075650, ). Associations exceeding the experiment-wide significance threshold ( ) were replicated in an additional 1,338 cases and 2,003 controls. The present study combines data on 483,399 single nucleotide polymorphisms (SNPs) from a previously reported GWAS of 492 LOAD cases and 496 controls and from an independent set of 439 LOAD cases and 608 controls to strengthen power to identify novel genetic association signals. However, until recently, variants at few other loci with statistically significant associations have replicated across studies. Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE. ![]()
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